Description

2-(1,1-Difluoroethyl)-1-Fluoro-4-Nitrobenzene is a high-value fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its unique difluoroethyl and nitro-substituted benzene structure makes it a critical building block for creating complex molecules with tailored properties. This compound is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic cores to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for synthesizing specialty polymers, liquid crystals, and advanced organic electronic materials that benefit from fluorinated components.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic aromatic substitutions, and reduction reactions to introduce complex fluorinated motifs into target molecules.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized fluorinated dyes and pigments that offer unique color fastness and optical properties.

Basic Information

Product Name	2-(1,1-Difluoroethyl)-1-Fluoro-4-Nitrobenzene
CAS No.	445303-19-5
Molecular Formula	C8H6F3NO2
Molecular Weight	205.14 g/mol
Synonyms	1-Fluoro-2-(1,1-difluoroethyl)-4-nitrobenzene; 4-Nitro-2-(1,1-difluoroethyl)fluorobenzene; 2-(1,1-Difluoroethyl)-4-nitrofluorobenzene; Benzene, 2-(1,1-difluoroethyl)-1-fluoro-4-nitro-; 445303-19-5; α,α-Difluoro-4-nitro-o-fluoroethylbenzene; o-Fluoro-α,α-difluoro-4-nitroethylbenzene
EINECS	Contact for details

Quality Control

Every batch of 2-(1,1-Difluoroethyl)-1-Fluoro-4-Nitrobenzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C/59-77°F). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 96.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.