Description

Ethanone, 1-[(1R,2R,4R)-2-Fluorobicyclo[2.2.1]Hept-5-En-2-Yl]-, Rel- (9Ci) is a high-purity, stereochemically defined fluorinated bicyclic ketone intermediate. This compound is valued for its unique structural framework, which is critical for imparting specific biological activity and physicochemical properties in advanced synthetic pathways. It is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral building block for the research and development of new therapeutic agents, particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorinated bicyclic structure can enhance bioavailability and environmental stability.
• Material Science Research: Serves as a precursor for specialty polymers and advanced organic materials requiring specific fluorinated motifs.
• Asymmetric Catalysis: Employed as a ligand or a substrate in stereoselective synthesis to construct complex chiral molecules.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme mechanisms and protein interactions due to its defined stereochemistry.
• Process Chemistry Development: Acts as a critical intermediate in scaling up synthetic routes for commercial production of fine chemicals.

Basic Information

Product Name	Ethanone, 1-[(1R,2R,4R)-2-Fluorobicyclo[2.2.1]Hept-5-En-2-Yl]-, Rel- (9Ci)
CAS No.	443141-74-0
Molecular Formula	C9H11FO
Molecular Weight	154.18 g/mol
Synonyms	1-[(1R,2R,4R)-2-Fluorobicyclo[2.2.1]hept-5-en-2-yl]ethanone; rel-(1R,2R,4R)-2-Acetyl-2-fluorobicyclo[2.2.1]hept-5-ene; 2-Fluoro-2-acetylbicyclo[2.2.1]hept-5-ene; (1R,2R,4R)-2-Fluoro-2-acetylbicyclo[2.2.1]hept-5-ene; Fluorinated Norbornene Ketone; Bicyclo[2.2.1]hept-5-ene-2-ethanol, 2-fluoro-, 2-acetate (rel-); CAS 443141-74-0
EINECS	Contact for details

Quality Control

Our Ethanone, 1-[(1R,2R,4R)-2-Fluorobicyclo[2.2.1]Hept-5-En-2-Yl]-, Rel- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC and GC, to ensure high chemical and stereochemical purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.