Description

Benzonitrile, 2-Fluoro-4-(1-Hydroxyethyl)- (9Ci) is a versatile fluorinated benzonitrile derivative, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its molecular structure, featuring both a nitrile and a secondary alcohol group, makes it highly valuable for constructing complex molecules with precise stereochemistry. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of novel drug candidates, especially in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty polymers and liquid crystals, where the fluorine and nitrile groups impart unique electronic and physical properties.
• Chemical Biology Probes: Useful for synthesizing fluorescent tags or molecular probes for studying biological processes and enzyme mechanisms.

Basic Information

Product Name	Benzonitrile, 2-Fluoro-4-(1-Hydroxyethyl)- (9Ci)
CAS No.	440105-59-9
Molecular Formula	C9H8FNO
Molecular Weight	165.16 g/mol
Synonyms	2-Fluoro-4-(1-hydroxyethyl)benzonitrile; 4-(1-Hydroxyethyl)-2-fluorobenzonitrile; 1-(4-Cyano-3-fluorophenyl)ethanol; α-Methyl-2-fluoro-4-cyanobenzyl alcohol; (RS)-1-(4-Cyano-3-fluorophenyl)ethanol; 2-Fluoro-4-(α-hydroxyethyl)benzonitrile; Benzonitrile, 2-fluoro-4-(1-hydroxyethyl)-
EINECS	Contact for details

Quality Control

Every batch of Benzonitrile, 2-Fluoro-4-(1-Hydroxyethyl)- (9Ci) is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and process development. A detailed Certificate of Analysis (COA), including results for chiral purity, enantiomeric excess (ee), and impurity profile by HPLC, is supplied with each shipment to guarantee reproducible performance and supply chain integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee (for chiral grades)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.