Description

3-Fluoro-5-Methoxybenzonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both electron-donating (methoxy) and electron-withdrawing (fluoro, nitrile) groups, makes it a valuable precursor for constructing complex molecules. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and inflammation.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Liquid Crystal & OLED Materials: Used in the research and production of advanced electronic display materials and organic light-emitting diodes (OLEDs) due to its aromatic and polarizable structure.
• Polymer Chemistry: Acts as a monomer or modifier in the synthesis of specialty polymers, including high-performance resins and engineering plastics.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic aromatic substitution to introduce functionalized aryl groups.
• Material Science Research: Investigated for use in the development of metal-organic frameworks (MOFs), sensors, and other functional materials.

Basic Information

Product Name	3-Fluoro-5-Methoxybenzonitrile
CAS No.	439280-18-9
Molecular Formula	C8H6FNO
Molecular Weight	151.14 g/mol
Synonyms	5-Cyano-1-fluoro-3-methoxybenzene; 1-Fluoro-3-methoxy-5-cyanobenzene; 3-Fluoro-5-methoxybenzenecarbonitrile; Benzonitrile, 3-fluoro-5-methoxy-; 3-Fluoro-5-methoxy phenyl cyanide
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-Methoxybenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.