Description

2-(2,3,4-Trifluoro-Phenyl)-1H-Imidazole CAS NO 438554-18-8 is a high-value, fluorinated heterocyclic building block characterized by its imidazole core linked to a multi-fluorinated phenyl ring. This specific substitution pattern makes it a critical intermediate for synthesizing advanced pharmaceutical compounds and agrochemicals, where the introduction of fluorine atoms is a key strategy for modulating biological activity, metabolic stability, and lipophilicity. It is primarily sought after by research and development chemists and process scale-up teams in the life sciences sector.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antifungal agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluorophenyl-imidazole moiety contributes to efficacy and environmental profile.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, or organic electronic materials due to its rigid, fluorinated aromatic structure.
• Chemical Biology & Proteomics: Employed as a scaffold or linker in the design of molecular probes, enzyme inhibitors, and bioconjugation reagents.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific fluorinated heterocycle.

Basic Information

Product Name	2-(2,3,4-Trifluoro-Phenyl)-1H-Imidazole
CAS No.	438554-18-8
Molecular Formula	C9H5F3N2
Molecular Weight	198.15 g/mol
Synonyms	2-(2,3,4-Trifluorophenyl)-1H-imidazole; 1H-Imidazole, 2-(2,3,4-trifluorophenyl)-; 2-(2,3,4-Trifluorophenyl)imidazole; 2-(2,3,4-Trifluorophenyl)-1H-imidazole; 438554-18-8; 2-(2,3,4-Trifluorophenyl)imidazole; 2-(2,3,4-Trifluorophenyl)-1H-imidazole; 2-(2,3,4-Trifluorophenyl)-1H-imidazole
EINECS	Contact for details

Quality Control

Every batch of 2-(2,3,4-Trifluoro-Phenyl)-1H-Imidazole is manufactured under a strict quality management system. We provide comprehensive analytical data including HPLC purity, NMR, and MS to confirm identity and quality. A Certificate of Analysis (COA) is supplied with each shipment, and we support customer audits and regulatory documentation needs for pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.