Description

(R)-4-Methoxy Propranolol CAS NO 437999-44-5 is a high-purity enantiomer of the β-adrenergic receptor antagonist propranolol, specifically modified with a methoxy group at the 4-position. This compound is of significant value as a key chiral intermediate and reference standard in advanced pharmaceutical research and development. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic laboratories engaged in the synthesis of novel β-blockers, metabolic studies, and the development of stereoselective analytical methods.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel β-adrenergic blocking agents (β-blockers) with potential improved efficacy or reduced side-effect profiles.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical laboratories for the identification and quantification of 4-methoxy propranolol metabolites in pharmacokinetic and drug metabolism studies.
• Pharmacological Research: Employed in preclinical research to study the stereospecific interactions, binding affinities, and functional activities of β-adrenergic receptors.
• Chiral Catalyst/Resolving Agent Development: Serves as a model substrate in the development and testing of new chiral separation techniques, including HPLC columns and catalysts for asymmetric synthesis.
• Quality Control & Regulatory Compliance: Essential as a certified reference material (CRM) for quality control testing of active pharmaceutical ingredients (APIs) and finished drug products to meet regulatory requirements (e.g., FDA, EMA).

Basic Information

Product Name	(R)-4-Methoxy Propranolol
CAS No.	437999-44-5
Molecular Formula	C17H21NO3
Molecular Weight	287.35 g/mol
Synonyms	(R)-1-Isopropylamino-3-(4-methoxyphenoxy)-2-propanol; (R)-4'-Methoxypropranolol; (R)-4-MOP; (2R)-1-[(1-Methylethyl)amino]-3-(4-methoxyphenoxy)-2-propanol; (R)-Methoxypropranolol; Dextro-4-Methoxy Propranolol; (R)-Propranolol 4-Methyl Ether
EINECS	Contact for details

Quality Control

Our (R)-4-Methoxy Propranolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (by HPLC), chiral excess, and related substances is provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R)-enantiomer
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.