Description

2,5-Difluoro-4-Formylbenzonitrile is a high-purity, multi-functional aromatic building block featuring both a formyl and a nitrile group on a difluorinated benzene ring. This unique structure makes it a critical intermediate for synthesizing advanced pharmaceutical compounds and high-performance materials. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for creating fluorinated components in electronic display materials and organic light-emitting diodes.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific chemical resistance, thermal stability, or optical properties.
• Cross-Coupling Reactions: The formyl and nitrile groups provide handles for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions.
• Organic Synthesis & Research: A versatile reagent for academic and industrial research in medicinal chemistry and material science.

Basic Information

Product Name	2,5-Difluoro-4-Formylbenzonitrile
CAS No.	433940-02-4
Molecular Formula	C8H3F2NO
Molecular Weight	167.11 g/mol
Synonyms	4-Cyano-2,5-difluorobenzaldehyde; 2,5-Difluoro-4-formylbenzonitrile; 2,5-Difluorobenzaldehyde-4-carbonitrile; 4-Formyl-2,5-difluorobenzonitrile; Benzonitrile, 2,5-difluoro-4-formyl-; 2,5-Difluoro-4-cyanobenzaldehyde
EINECS	Contact for details

Quality Control

Our 2,5-Difluoro-4-Formylbenzonitrile is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically exceeding 97% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP standards where applicable, and our quality management system is designed to meet the stringent requirements of pharmaceutical and advanced material supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.