Description

3-Chloro-5-(Trifluoromethoxy)Phenylacetonitrile is a versatile and high-value fluorinated aromatic nitrile building block. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemical active ingredients due to its unique trifluoromethoxy and chloro substituents, which impart desirable biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in CNS and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Building block for next-generation herbicides, fungicides, and insecticides, leveraging the trifluoromethoxy group for enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science Precursor: Serves as a monomer or functionalization agent for advanced polymers and liquid crystals.
• Custom Synthesis and Contract Manufacturing: Employed in research-scale and pilot-scale custom synthesis projects for specialized client molecules.

Basic Information

Product Name	3-Chloro-5-(Trifluoromethoxy)Phenylacetonitrile
CAS No.	433938-69-3
Molecular Formula	C9H5ClF3NO
Molecular Weight	235.59 g/mol
Synonyms	2-[3-Chloro-5-(trifluoromethoxy)phenyl]acetonitrile; (3-Chloro-5-(trifluoromethoxy)phenyl)acetonitrile; 3-Chloro-5-trifluoromethoxyphenylacetonitrile; α-Cyano-3-chloro-5-(trifluoromethoxy)toluene; 3-Chloro-α-cyano-5-(trifluoromethoxy)toluene; 2-(3-Chloro-5-(trifluoromethoxyl)phenyl)acetonitrile
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-5-(Trifluoromethoxy)Phenylacetonitrile is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.