Description

4,5-Difluoro-2-Methoxybenzonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring strategically placed fluorine atoms and a methoxy group, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, anti-cancer agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the difluoro-methoxybenzonitrile moiety can enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated liquid crystal compounds and organic light-emitting diode (OLED) materials, contributing to improved performance and stability.
• Functional Material Research: Employed in academic and industrial R&D for creating advanced polymers, ligands for catalysis, and other specialty chemicals requiring a rigid, electron-deficient aromatic core.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up campaigns in fine chemical production.

Basic Information

Product Name	4,5-Difluoro-2-Methoxybenzonitrile
CAS No.	425702-28-9
Molecular Formula	C9H5F2NO
Molecular Weight	181.14 g/mol
Synonyms	2-Methoxy-4,5-difluorobenzonitrile; 4,5-Difluoro-2-methoxybenzonitrile; Benzonitrile, 4,5-difluoro-2-methoxy-; 2-Methoxy-4,5-difluorobenzene carbonitrile
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-2-Methoxybenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring reliable and consistent performance in critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.