Description

2-Bromo-3,5-Difluorobenzonitrile is a high-value, multi-functional aromatic building block featuring a bromine substituent and two fluorine atoms on the benzonitrile core. This compound is critical for introducing specific steric and electronic properties into target molecules, enabling advanced material and pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in cross-coupling reactions and as a precursor for complex heterocycles.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluorobenzonitrile moiety.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the bromine atom facilitates further functionalization.
• Material Science Research: Serves as a precursor for liquid crystals, organic semiconductors, and polymers where fluorine substitution enhances stability and electronic properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to create complex biaryl structures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for imaging and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Bromo-3,5-Difluorobenzonitrile
CAS No.	425379-37-9
Molecular Formula	C7H2BrF2N
Molecular Weight	218.00 g/mol
Synonyms	2-Bromo-3,5-difluorobenzonitrile; 3,5-Difluoro-2-bromobenzonitrile; Benzonitrile, 2-bromo-3,5-difluoro-; 425379-37-9; 2-Bromo-3,5-difluorophenyl cyanide; 2-Bromo-3,5-difluorobenzene carbonitrile
EINECS	Contact for details

Quality Control

Our 2-Bromo-3,5-Difluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.