Description

2-Cyano-5-Fluorobenzylbromide is a versatile and highly functionalized benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its molecular architecture, featuring both a reactive bromomethyl group and an electron-withdrawing cyano substituent on a fluorinated aromatic ring, makes it indispensable for constructing complex pharmacophores. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine and cyano groups enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials due to its aromatic and polarizable nature.
• Custom Synthesis and Contract Manufacturing: A valuable reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Cyano-5-Fluorobenzylbromide
CAS No.	421552-12-7
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	5-Fluoro-2-cyanobenzyl bromide; (5-Fluoro-2-cyanophenyl)methyl bromide; 2-Cyano-5-fluorobenzyl bromide; 1-(Bromomethyl)-5-fluoro-2-cyanobenzene; α-Bromo-5-fluoro-o-tolunitrile; 5-Fluoro-2-(bromomethyl)benzonitrile
EINECS	Contact for details

Quality Control

Every batch of 2-Cyano-5-Fluorobenzylbromide is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.