Description

2-Fluoro-4-(Methylthio)Benzonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a fluorine atom and a methylthio group, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing fluorine into bioactive molecules to modulate metabolism, bioavailability, and binding affinity.
• Agrochemical Synthesis: Serves as a building block for novel herbicides, fungicides, and insecticides, where the fluorine and sulfur-containing groups can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Research: Used in the development of advanced electronic materials, where its polarizable structure contributes to the desired electro-optical properties.
• Functional Polymer Monomer: Employed in the synthesis of specialty polymers with specific chemical resistance or surface properties.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Stille) due to the reactive cyano and methylthio groups, enabling diverse molecular architectures.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D labs exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	2-Fluoro-4-(Methylthio)Benzonitrile
CAS No.	411233-39-1
Molecular Formula	C8H6FNS
Molecular Weight	167.20 g/mol
Synonyms	4-(Methylthio)-2-fluorobenzonitrile; 2-Fluoro-4-methylthiobenzonitrile; 4-Methylsulfanyl-2-fluorobenzonitrile; Benzonitrile, 2-fluoro-4-(methylthio)-; 2-Fluoro-4-(methylsulfanyl)benzonitrile; 2-Fluoro-4-(methylmercapto)benzonitrile; 2-Fluoro-4-(methylthio)phenyl cyanide
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-(Methylthio)Benzonitrile is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request. We are committed to meeting the stringent requirements of research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and fluorides. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.