Description

4-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)-2-(Trifluoromethyl)Benzonitrile (Wxc06127) is a high-purity, functionalized pyrrolidine derivative featuring a reactive maleimide group and a trifluoromethyl-substituted benzonitrile moiety. This compound is a critical building block in advanced organic synthesis, valued for its ability to act as a Michael acceptor and participate in click chemistry reactions, particularly for bioconjugation and polymer modification. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Serves as a key synthon for the development of targeted drug candidates, especially in oncology and CNS diseases, leveraging the maleimide group for antibody-drug conjugate (ADC) linker technology.
• Bioconjugation Reagent: Used for site-specific labeling of proteins, peptides, and antibodies via thiol-maleimide chemistry, essential for diagnostic assays and targeted therapeutics.
• Polymer Science: Acts as a functional monomer or cross-linking agent in the synthesis of advanced polymers with tailored properties, such as hydrogels, coatings, and specialty resins.
• Agrochemical Synthesis: Employed in the research and development of novel herbicides and pesticides, where the trifluoromethyl group often enhances biological activity and metabolic stability.
• Material Science Research: Utilized in surface modification and the creation of functionalized nanomaterials for sensors, catalysts, and electronic applications.
• Chemical Biology Probes: Facilitates the development of activity-based probes and affinity labels for studying enzyme function and protein-protein interactions.

Basic Information

Item	Details
Product Name	4-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)-2-(Trifluoromethyl)Benzonitrile (Wxc06127)
CAS No.	406224-65-5
Molecular Formula	C13H5F3N2O2
Molecular Weight	278.19 g/mol
Synonyms	2-(Trifluoromethyl)-4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzonitrile; 1-[4-Cyano-3-(trifluoromethyl)phenyl]-1H-pyrrole-2,5-dione; N-(4-Cyano-3-trifluoromethylphenyl)maleimide; 4-Maleimidobenzotrifluoride; WXC-06127; 406224-65-5; 4-(2,5-Dioxopyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile
EINECS	Contact for details

Quality Control

Every batch of 4-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)-2-(Trifluoromethyl)Benzonitrile is manufactured under a strict quality management system. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as confirmed by advanced analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation. Keep away from incompatible materials such as strong bases and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.