Description

n-(4-Cyano-2-Fluorophenyl)Methanesulfonamide is a high-purity, advanced pharmaceutical intermediate characterized by its distinct sulfonamide and cyano-fluorophenyl structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to develop next-generation drugs, leveraging its unique chemical functionality for creating potent and selective candidates.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the research and synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Kinase Inhibitor Development: Serves as a core scaffold in the design and production of potential kinase inhibitors for oncology and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, where the fluorophenyl and sulfonamide groups contribute to biological activity.
• Material Science Research: Employed in academic and industrial R&D for creating specialized polymers or organic electronic materials.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and contract research organizations (CROs/CMOs) serving the life sciences sector.

Basic Information

Product Name	n-(4-Cyano-2-Fluorophenyl)Methanesulfonamide
CAS No.	401909-16-8
Molecular Formula	C8H7FN2O2S
Molecular Weight	214.22 g/mol
Synonyms	4-Cyano-2-fluoro-N-(methylsulfonyl)aniline; 2-Fluoro-4-cyanophenylmethanesulfonamide; Methanesulfonamide, N-(4-cyano-2-fluorophenyl)-; 401909-16-8; N-(4-Cyano-2-fluorophenyl)methanesulfonamide; 2-Fluoro-4-cyanobenzenemethanesulfonamide; 4-Cyano-2-fluorobenzenemethanesulfonamide
EINECS	Contact for details

Quality Control

Our n-(4-Cyano-2-Fluorophenyl)Methanesulfonamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the original container tightly sealed in a dry environment. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.