Description

(R)-(+)-2-Amino-1-Fluoro-3-Methyl-1,1-Diphenylbutane is a high-purity, chiral fluorinated amine building block of significant interest in advanced organic synthesis. Its value lies in its unique stereochemistry and fluorine atom, which are critical for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced, enantiomerically pure herbicides, fungicides, and insecticides where specific stereochemistry enhances efficacy.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to induce high enantioselectivity.
• Fluorine Chemistry Research: An important compound for studying the effects of fluorine introduction on molecular conformation and interaction in medicinal chemistry.
• Peptidomimetics and Bioisosteres: Employed in the design of peptide mimics and bioisosteric replacements to improve drug-like properties.
• Academic and Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting cutting-edge synthetic methodology and medicinal chemistry projects.

Basic Information

Product Name	(R)-(+)-2-Amino-1-Fluoro-3-Methyl-1,1-Diphenylbutane
CAS No.	400870-24-8
Molecular Formula	C17H20FN
Molecular Weight	257.35 g/mol
Synonyms	(R)-2-Amino-1-fluoro-3-methyl-1,1-diphenylbutane; (R)-(+)-1-Fluoro-2-amino-3-methyl-1,1-diphenylbutane; (R)-1-Fluoro-2-amino-3-methyl-1,1-diphenylbutane; (R)-α-Fluoro-β-amino-1,1-diphenyl-3-methylbutane; (R)-1,1-Diphenyl-1-fluoro-3-methyl-2-aminobutane; (R)-FDPAB; (R)-F-DPAB; (R)-FDPAB-NH2
EINECS	Contact for details

Quality Control

Our (R)-(+)-2-Amino-1-Fluoro-3-Methyl-1,1-Diphenylbutane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.