Description

17,21-Dihydroxypregna-1,4-Diene-3,20-Dione 17-Acetate is a high-purity steroid derivative of significant interest in pharmaceutical research and development. This compound serves as a crucial synthetic intermediate for the production of more complex steroid-based active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of corticosteroids and other therapeutic agents. Our supply is characterized by stringent quality control to ensure reliability and consistency for critical applications.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent corticosteroid drugs.
• Research & Development: Used in academic and industrial laboratories for studying steroid metabolism, structure-activity relationships (SAR), and developing new therapeutic candidates.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of steroid APIs.
• Biochemical Research: Utilized in studies investigating hormonal pathways and receptor interactions.

Basic Information

Product Name	17,21-Dihydroxypregna-1,4-Diene-3,20-Dione 17-Acetate
CAS No.	49751-53-3
Molecular Formula	C23H30O6
Molecular Weight	402.48 g/mol
Synonyms	Prednisolone 17-Acetate; 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione 17-acetate; 17α-Acetoxyprednisolone; 1,4-Pregnadiene-11β,17α,21-triol-3,20-dione 17-acetate; δ1-Hydrocortisone 17-acetate; NSC 10483; Prednisolone acetate (17-isomer)
EINECS	256-450-9

Quality Control

Our 17,21-Dihydroxypregna-1,4-Diene-3,20-Dione 17-Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for that batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.