Description

3-Amino-5-(Trifluoromethyl)Benzonitrile is a high-value aromatic nitrile building block featuring both an amino group and a trifluoromethyl substituent. This unique structure makes it a critical intermediate for synthesizing advanced pharmaceutical compounds and agrochemicals, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily sought by R&D chemists and process development teams in the life sciences and specialty chemical sectors.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers and functional materials with specific electronic or surface properties.
• Fluorine Chemistry: A valuable substrate for further functionalization in fluorochemical research, enabling the creation of complex fluorinated molecules.

Basic Information

Product Name	3-Amino-5-(Trifluoromethyl)Benzonitrile
CAS No.	49674-28-4
Molecular Formula	C8H5F3N2
Molecular Weight	186.14 g/mol
Synonyms	5-(Trifluoromethyl)-3-aminobenzonitrile; 3-Amino-α,α,α-trifluoro-m-toluonitrile; 3-Cyano-5-(trifluoromethyl)aniline; 3-Amino-5-trifluoromethylbenzonitrile; m-Amino-α,α,α-trifluorobenzonitrile; Benzonitrile, 3-amino-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-1,3-phenylenediamine-1-carbonitrile
EINECS	Contact for details

Quality Control

Our 3-Amino-5-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.