Description

4-(Trifluoromethoxy)Phenylacetonitrile is a versatile fluorinated aromatic nitrile building block, essential for introducing the trifluoromethoxy-phenyl moiety into complex molecular architectures. Its primary value lies in enabling the synthesis of advanced pharmaceutical intermediates and agrochemicals, where the trifluoromethoxy group enhances metabolic stability and lipophilicity. This high-purity intermediate is critically needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Key precursor for the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, anti-inflammatory agents, and other therapeutic areas.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, where the trifluoromethoxy group improves biological activity and environmental persistence.
• Liquid Crystal Materials: Used in the development of fluorinated components for advanced liquid crystal displays (LCDs) due to its polarizability and stability.
• Organic Electronics: Serves as a starting material for electron-transport materials and other functional components in OLEDs and organic photovoltaics.
• Advanced Material Research: Employed in academic and industrial R&D for creating novel polymers, ligands, and metal-organic frameworks (MOFs) with specific fluorinated properties.
• Custom Synthesis & Contract Manufacturing: A critical raw material for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	4-(Trifluoromethoxy)Phenylacetonitrile
CAS No.	49561-96-8
Molecular Formula	C9H6F3NO
Molecular Weight	201.15 g/mol
Synonyms	4-(Trifluoromethoxy)benzyl cyanide; (4-Trifluoromethoxyphenyl)acetonitrile; α-Cyano-4-(trifluoromethoxy)toluene; 2-[4-(Trifluoromethoxy)phenyl]acetonitrile; p-(Trifluoromethoxy)phenylacetonitrile; 4-(Trifluoromethoxy)benzenecetonitrile; NSC 405124
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethoxy)Phenylacetonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically exceeding 98% (by HPLC). Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality commitment supports compliance with global regulatory frameworks such as REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.