Description

(-)-Bucumolol is a potent and stereospecific β-adrenergic receptor antagonist (β-blocker) of significant interest in pharmaceutical research and development. Its high biological activity makes it a critical intermediate for synthesizing novel cardiovascular agents and for studying adrenergic receptor mechanisms. This compound is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug discovery, pharmacology studies, and the production of reference standards.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced β-blocker drug candidates and active pharmaceutical ingredients (APIs).
• Biochemical Research: Tool compound for in vitro and in vivo studies targeting β-1 and β-2 adrenergic receptors to investigate cardiac and pulmonary functions.
• Reference Standard: Used as a high-purity calibration standard in analytical method development and quality control (QC) laboratories for HPLC, LC-MS, and NMR.
• Preclinical Development: Employed in pharmacokinetic, pharmacodynamic, and toxicology studies during early-stage drug development.
• Academic Research: Facilitates studies in medicinal chemistry, pharmacology, and molecular biology within university and institutional labs.

Basic Information

Product Name	(-)-Bucumolol
CAS No.	47208-47-9
Molecular Formula	C18H29NO4
Molecular Weight	323.43 g/mol
Synonyms	(-)-Bucumolol; (S)-Bucumolol; Levobucumolol; 1-(tert-Butylamino)-3-[(2S)-2-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalen-1-yl]oxypropan-2-ol; K-5103; YM-09538; (S)-1-(tert-Butylamino)-3-[(5,8-dimethoxy-2-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl)oxy]-2-propanol
EINECS	Contact for details

Quality Control

Our (-)-Bucumolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.