Description

(+)-Bucumolol CAS NO 47208-46-8 is a high-purity enantiomer of the β-adrenergic receptor antagonist bucumolol. This specific stereoisomer is of significant interest for advanced pharmaceutical research and development, particularly in studying stereospecific drug-receptor interactions and metabolic pathways. It serves as a critical chiral building block and reference standard for scientists in medicinal chemistry, pharmacology, and analytical development.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for quality control and assay validation in the production of β-blocker medications.
• Medicinal Chemistry Research: A key chiral intermediate for the synthesis and structure-activity relationship (SAR) studies of novel cardiovascular drugs.
• Pharmacological Studies: Employed in preclinical research to investigate the stereoselective effects, potency, and metabolism of β-adrenergic antagonists.
• Analytical Method Development: Serves as a pure standard for developing and calibrating chromatographic methods (e.g., Chiral HPLC) for enantiomeric purity analysis.
• Academic Research: Utilized in university and institutional labs for biochemical and pharmacological teaching and advanced research projects.

Basic Information

Product Name	(+)-Bucumolol
CAS No.	47208-46-8
Molecular Formula	C20H29NO3
Molecular Weight	331.45 g/mol
Synonyms	(+)-Bucumolol; (R)-Bucumolol; (R)-5-[3-(tert-Butylamino)-2-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone; 1(2H)-Naphthalenone, 5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-, (R)-; Bucumolol, (+)-; Dextro-bucumolol; (R)-(+)-Bucumolol; YM-09538
EINECS	Contact for details

Quality Control

Our (+)-Bucumolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.