Description

Levobunolol is a potent, non-selective β-adrenergic receptor antagonist (β-blocker) used primarily as an active pharmaceutical ingredient (API). Its core value lies in its effective reduction of intraocular pressure, making it a critical component in ophthalmic solutions for treating glaucoma and ocular hypertension. This high-purity compound is essential for pharmaceutical manufacturers developing sterile, preservative-free eye drops and other advanced ophthalmic formulations.

Application

• Ophthalmic Solutions: Primary use as the active ingredient in prescription eye drops for the management of chronic open-angle glaucoma and ocular hypertension.
• Pharmaceutical Intermediates: Serves as a key chiral building block in the synthesis of more complex β-blocker molecules and related therapeutic agents.
• Research & Development: Utilized in preclinical and clinical studies investigating adrenergic receptor pharmacology and new drug delivery systems.
• Generic Drug Manufacturing: Sourced by API manufacturers for the production of generic ophthalmic medications, ensuring cost-effective treatment options.
• Veterinary Medicine: Potential application in veterinary ophthalmology for similar intraocular pressure-lowering effects in animals.

Basic Information

Product Name	Levobunolol
CAS No.	47141-42-4
Molecular Formula	C17H25NO3
Molecular Weight	291.39 g/mol
Synonyms	(-)-Levobunolol; L-Bunolol; (S)-(-)-5-[3-(tert-Butylamino)-2-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone; Levobunolol Hydrochloride (salt form); L-640,066; Betagan (brand name reference); Vistagan (brand name reference); (S)-Bunolol
EINECS	Contact for details

Quality Control

Our Levobunolol is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical actives. Quality is verified through comprehensive analytical testing, including chiral purity determination, assay, and control of specified impurities. A Certificate of Analysis (COA) detailing results against relevant pharmacopeial standards (such as USP/EP) is provided with each batch to guarantee traceability, consistency, and regulatory compliance for our global customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5%; Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.