Description

(+)-Trimeprazine CAS NO 47138-20-5 is the dextrorotatory enantiomer of the phenothiazine derivative trimeprazine, a compound of significant interest in pharmaceutical research and development. This specific stereoisomer is valued for its distinct pharmacological profile and serves as a crucial chiral building block and reference standard. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in advanced medicinal chemistry, enantioselective synthesis, and neuropharmacology studies.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for analytical method development, validation, and quality control (QC) in drug manufacturing.
• Chiral Intermediate: Serves as a key starting material or intermediate in the enantioselective synthesis of novel therapeutic agents targeting the central nervous system.
• Pharmacological Research: Employed in preclinical studies to investigate the stereospecific effects of phenothiazine derivatives on histamine (H1) and other neurotransmitter receptors.
• Metabolite Studies: Utilized as a precursor or standard in the identification and quantification of drug metabolites during ADME (Absorption, Distribution, Metabolism, and Excretion) profiling.
• Impurity Profiling: Acts as a critical impurity standard to monitor and control the enantiomeric purity of racemic trimeprazine or related pharmaceutical products.

Basic Information

Product Name	(+)-Trimeprazine
CAS No.	47138-20-5
Molecular Formula	C18H22N2S
Molecular Weight	298.45 g/mol
Synonyms	(+)-Trimeprazine; Dextro-Trimeprazine; (R)-Trimeprazine; (+)-Alimemazine; (+)-Temaril; (+)-Panectyl; (+)-Vallergan; 10-[3-(Dimethylamino)-2-methylpropyl]phenothiazine (dextrorotatory form)
EINECS	Contact for details

Quality Control

Our (+)-Trimeprazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay and identification, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing batch-specific results for identity, purity, and enantiomeric excess is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.