Description

(R)-Bunitrolol is the single enantiomer form of the β-adrenergic receptor antagonist bunitrolol, distinguished by its specific (R)-configuration. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the study of stereoselective drug activity and metabolism. It is primarily utilized by advanced research laboratories and pharmaceutical companies engaged in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and for pharmacological profiling.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiomerically pure β-blocker APIs.
• Pharmacological Research: Used as a reference standard in studies investigating the stereospecific binding and activity of β-adrenergic antagonists.
• Metabolite Studies: Employed in ADME (Absorption, Distribution, Metabolism, Excretion) research to understand the metabolic pathways of chiral drugs.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for analytical method development and validation in chiral separations (e.g., HPLC, CE).
• Asymmetric Synthesis: A valuable starting material or model compound for developing new catalytic asymmetric synthesis routes.

Basic Information

Product Name	(R)-Bunitrolol
CAS No.	46905-83-3
Molecular Formula	C17H20N2O3
Molecular Weight	300.35 g/mol
Synonyms	(R)-1-(2,5-Dimethoxyphenyl)-2-tert-butylamino-1-propanol; (R)-1-(2,5-Dimethoxyphenyl)-2-(tert-butylamino)propan-1-ol; (R)-Bunitrolol; (R)-Bunitrololum; D-Bunitrolol; (+)-Bunitrolol; (R)-(-)-1-(2,5-Dimethoxyphenyl)-2-(tert-butylamino)propanol; Koe 1366 (R-enantiomer)
EINECS	Contact for details

Quality Control

Our (R)-Bunitrolol is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) specifying identity, purity (typically ≥98%), enantiomeric excess (ee), and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.