Description

Hydrogen Fluoride 2,4,6-Collidine Complex is a stabilized, solid-source reagent for anhydrous hydrogen fluoride. This compound matters because it provides a safe and convenient method to handle HF, a highly corrosive and toxic gas, in a controlled solid form for critical synthetic transformations. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for fluorination and deprotection reactions.

Application

• Fluorination Reagent: Used as a source of anhydrous HF for the selective introduction of fluorine atoms into organic molecules in drug discovery.
• Peptide Synthesis: Employed for the final cleavage and deprotection of peptides from solid-phase resin, offering advantages over traditional liquid HF methods.
• Oligonucleotide Synthesis: Facilitates the deprotection of synthetic oligonucleotides in a safer, more manageable format.
• Catalyst and Reagent in Organic Synthesis: Acts as a mild acid catalyst or a fluoride source in various condensation and cyclization reactions.
• Material Science Research: Used in the surface treatment and etching studies of silicon-based materials under controlled conditions.
• Reference Standard: Serves as a high-purity chemical standard for analytical method development and quality control in fine chemical production.

Basic Information

Product Name	Hydrogen Fluoride 2,4,6-Collidine Complex
CAS No.	45725-47-1
Molecular Formula	C8H12F4N2
Molecular Weight	212.19 g/mol
Synonyms	HF-Collidine Complex; HF-2,4,6-Trimethylpyridine Complex; Anhydrous Hydrogen Fluoride-2,4,6-Collidine Adduct; 2,4,6-Trimethylpyridine Hydrofluoride; Collidine Hydrofluoride; Pyridine, 2,4,6-trimethyl-, hydrofluoride (1:?); Solid HF Source Reagent
EINECS	Contact for details

Quality Control

Our Hydrogen Fluoride 2,4,6-Collidine Complex is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a dry environment to maintain stability. Keep away from strong alkalis.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.