Description

Chlorpheniramine CAS NO 42882-96-2 is a first-generation alkylamine antihistamine widely recognized for its potent H1-receptor antagonism. It is a critical active pharmaceutical ingredient (API) valued for its efficacy in managing allergic conditions and its role as a foundational component in multi-symptom relief formulations. This compound is essential for pharmaceutical manufacturers, contract research organizations (CROs), and developers of over-the-counter (OTC) and prescription medications targeting allergic rhinitis, urticaria, and the common cold.

Application

• Pharmaceutical API: Primary active ingredient in prescription and OTC antihistamine tablets, syrups, and injectables.
• Allergy & Cold Medications: Key component in multi-ingredient formulations for symptomatic relief of sneezing, runny nose, and itchy/watery eyes.
• Veterinary Pharmaceuticals: Used in antihistamine preparations for allergic reactions in animals.
• Research & Development: Reference standard and building block in pharmacological research for studying histamine pathways and developing new therapeutic agents.
• Controlled-Release Formulations: Incorporated into extended-release drug delivery systems for prolonged therapeutic effect.

Basic Information

Product Name	Chlorpheniramine
CAS No.	42882-96-2
Molecular Formula	C16H19ClN2
Molecular Weight	274.79 g/mol
Synonyms	Chlorphenamine; Chlor-Trimeton; Piriton; Aller-Chlor; Teldrin; 1-(4-Chlorophenyl)-1-(2-pyridinyl)-3-(dimethylamino)propane; γ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine; Histafen
EINECS	255-991-8

Quality Control

Our Chlorpheniramine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards, including identification, assay, and impurity profile analysis. We provide full traceability and support compliance with major pharmacopoeial standards such as USP, EP, and BP. A detailed Certificate of Analysis (COA) is available for every shipment to guarantee product integrity and specification adherence.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.