Description

4-[2-Amino-4-(Trifluoromethyl)Phenoxy]Benzonitrile is a high-purity, specialized organic intermediate featuring a unique trifluoromethyl-substituted aromatic structure. This compound matters for its role as a critical building block in the synthesis of advanced molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on novel active ingredients, where its specific substitution pattern enables the fine-tuning of biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a vital building block for developing new herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group to enhance metabolic stability and lipophilicity.
• Material Science Research: Used in the development of advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) components and liquid crystals.
• Dye and Pigment Intermediate: Employed in the synthesis of specialized dyes and pigments where the amino and nitrile groups allow for further functionalization.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) for creating complex biaryl structures.

Basic Information

Product Name	4-[2-Amino-4-(Trifluoromethyl)Phenoxy]Benzonitrile
CAS No.	42874-97-5
Molecular Formula	C14H9F3N2O
Molecular Weight	278.23 g/mol
Synonyms	2-Amino-4-(trifluoromethyl)phenyl 4-cyanophenyl ether; 4-Cyano-2'-amino-4'-(trifluoromethyl)diphenyl ether; Benzonitrile, 4-[2-amino-4-(trifluoromethyl)phenoxy]-; 4-(2-Amino-4-trifluoromethylphenoxy)benzonitrile; 2-Amino-α,α,α-trifluoro-p-tolyl 4-cyanophenyl ether; 4-(2-Amino-4-(trifluoromethyl)phenoxy)benzonitrile
EINECS	Contact for details

Quality Control

Our 4-[2-Amino-4-(Trifluoromethyl)Phenoxy]Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.