Description

Nafetolol CAS NO 42050-23-7 is a selective β-adrenergic receptor antagonist (β-blocker) of significant interest in pharmaceutical research and development. This compound is valued for its potential cardiovascular activity and serves as a critical intermediate or active pharmaceutical ingredient (API) in the synthesis of advanced therapeutic agents. It is primarily utilized by pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in cardiovascular drug discovery and production.

Application

• Pharmaceutical API Synthesis: Key intermediate or active ingredient in the production of β-blocker medications.
• Cardiovascular Research: Used in preclinical and clinical studies targeting hypertension, angina, and arrhythmias.
• Metabolite & Impurity Standard: Serves as a reference standard in analytical method development and quality control for related drug substances.
• Formulation Development: Employed in the development of various dosage forms such as tablets and capsules.
• Biochemical Tool Compound: Used in pharmacological assays to study β-adrenergic receptor mechanisms and selectivity.

Basic Information

Item	Detail
Product Name	Nafetolol
CAS No.	42050-23-7
Molecular Formula	C15H24N2O3
Molecular Weight	280.36 g/mol
Synonyms	Nafetolol; 1-(2,3-Dihydro-1,4-benzodioxin-6-yloxy)-3-[(1-methylethyl)amino]-2-propanol; 42050-23-7; (±)-Nafetolol; DL-Nafetolol; UNII-7K8I1B516N; BRN 2932438; CHEBI:135896
EINECS	Contact for details

Quality Control

Our Nafetolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including identification, assay, and impurity profiling to ensure it meets high-purity standards suitable for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.