Description

2-(Difluoromethoxy)Phenylacetonitrile is a versatile fluorinated aromatic nitrile building block, essential for advanced organic synthesis. Its unique difluoromethoxy substituent adjacent to the reactive cyano group makes it a critical intermediate for introducing specific structural motifs into target molecules. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those requiring difluoromethoxy-phenyl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the difluoromethoxy group can improve lipophilicity and biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Cross-Coupling Reactions: The benzylic position and aromatic ring are amenable to various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) for constructing complex molecular architectures.
• Nitrile Transformation Chemistry: The cyano group can be readily converted into carboxylic acids, amides, amines, or tetrazoles, enabling diverse downstream functionalization.
• Fluorine Chemistry Research: A valuable substrate for studying the effects of fluorine substitution on chemical reactivity and physical properties in academic and industrial R&D settings.

Basic Information

Product Name	2-(Difluoromethoxy)Phenylacetonitrile
CAS No.	41429-22-5
Molecular Formula	C9H7F2NO
Molecular Weight	183.15 g/mol
Synonyms	2-(Difluoromethoxy)benzyl cyanide; α-Cyano-2-(difluoromethoxy)toluene; (2-(Difluoromethoxy)phenyl)acetonitrile; Benzeneacetonitrile, 2-(difluoromethoxy)-; 2-(Difluoromethoxy)benzeneacetonitrile; o-(Difluoromethoxy)phenylacetonitrile; DFMPAN; DFM-PAN
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)Phenylacetonitrile is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and strong reducing agents. The container should be kept tightly closed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.