Description

Cyproheptadine Hydrochloride Sesquihydrate is a pharmaceutical-grade antihistamine and antiserotonergic agent, widely recognized for its therapeutic efficacy. This compound is critical for the development and production of medications targeting allergic conditions and appetite stimulation. It is primarily required by pharmaceutical manufacturers, research institutions, and compounding facilities for the formulation of tablets, syrups, and other dosage forms.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the manufacture of prescription and over-the-counter antihistamine medications.
• Allergy Treatment Formulations: Key component in drugs for treating symptoms of allergic rhinitis, conjunctivitis, and chronic urticaria.
• Appetite Stimulant: Used in therapeutic applications to promote weight gain and manage appetite loss in clinical settings.
• Migraine Prophylaxis: Incorporated into treatments for the prevention of migraine and cluster headaches.
• Veterinary Medicine: Applied in veterinary pharmaceuticals for allergic and dermatological conditions in animals.
• Biochemical Research: Serves as a reference standard and a tool for studying histamine and serotonin receptor antagonism in laboratory research.
• Compounding Pharmacy: Utilized by specialized pharmacies for preparing customized patient-specific medications.

Basic Information

Product Name	Cyproheptadine Hydrochloride Sesquihydrate
CAS No.	41354-29-4
Molecular Formula	C21H21N·HCl·1½H2O
Molecular Weight	350.87 g/mol (for sesquihydrate)
Synonyms	Cyproheptadine HCl Sesquihydrate; Periactin; Nuran; 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine Hydrochloride Sesquihydrate; (3b)-1-Methyl-4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidine Hydrochloride Sesquihydrate; Cipractin; Vimicon; Antegan; Practin
EINECS	Contact for details

Quality Control

Our Cyproheptadine Hydrochloride Sesquihydrate is manufactured under strict quality systems to meet the rigorous standards of the pharmaceutical industry. Each batch is tested to ensure compliance with relevant pharmacopeial specifications such as USP/EP. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	6.0% - 8.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.