Description

1-Iodo-3-Nitro-5-Benzotrifluoride is a versatile halogenated aromatic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic positioning of three distinct functional groups—iodo, nitro, and trifluoromethyl—which enable precise, multi-step derivatization for creating complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who require high-purity intermediates for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl and nitro groups.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers and liquid crystals with unique electronic or optical properties.
• Organic Synthesis Building Block: The iodine atom facilitates further functionalization via cross-coupling reactions (e.g., Suzuki, Heck), making it invaluable for constructing complex, poly-substituted aromatic systems in medicinal chemistry.
• Dye and Pigment Intermediate: Employed in the synthesis of specialized dyes and pigments where the electron-withdrawing groups influence color and stability.

Basic Information

Product Name	1-Iodo-3-Nitro-5-Benzotrifluoride
CAS No.	41253-01-4
Molecular Formula	C7H3F3INO2
Molecular Weight	316.99 g/mol
Synonyms	3-Nitro-5-(trifluoromethyl)iodobenzene; 1-Iodo-3-nitro-5-(trifluoromethyl)benzene; 5-Iodo-3-nitrobenzotrifluoride; 3-Nitro-α,α,α-trifluoro-5-iodotoluene; 3-Nitro-5-trifluoromethyliodobenzene; Iodo-nitro-benzotrifluoride; 41253-01-4
EINECS	Contact for details

Quality Control

Our 1-Iodo-3-Nitro-5-Benzotrifluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, and NMR is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.