Description

N1-(3-Aminopropyl)Bleomycinamide is a chemically modified derivative of the bleomycin family, designed to introduce a reactive primary amine group for targeted conjugation. This functionalization is critical for creating advanced drug-linker complexes in antibody-drug conjugate (ADC) development and targeted therapeutic applications. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of next-generation oncology treatments and precision bioconjugates.

Application

• Antibody-Drug Conjugate (ADC) Payload-Linker Synthesis: Serves as a key intermediate for constructing cleavable or non-cleavable linkers, enabling the attachment of cytotoxic agents to monoclonal antibodies.
• Targeted Cancer Therapy Research: Used in preclinical and research settings to develop novel chemotherapeutic agents with improved specificity and reduced systemic toxicity.
• Bioconjugation and Protein Labeling: The reactive aminopropyl group facilitates covalent attachment to various biomolecules, peptides, or fluorescent probes for diagnostic and research applications.
• Pharmaceutical Intermediate: Acts as a crucial building block in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) with enhanced pharmacological properties.
• Chemical Biology Tool: Employed in studying DNA cleavage mechanisms and the structure-activity relationships of bleomycin analogs.

Basic Information

Product Name	N1-(3-Aminopropyl)Bleomycinamide
CAS No.	41138-53-8
Molecular Formula	C58H92N20O21S2 (Bleomycin A2 derivative)
Molecular Weight	Contact for details
Synonyms	Bleomycin A2, 3-Aminopropylamide; AP-Bleomycin; Bleomycin A2 Aminopropylamide; N1-(3-Aminopropyl)bleomycin A2 amide; 3-Aminopropyl-bleomycinamide; Bleomycin derivative AP; N-(3-Aminopropyl)bleomycinamide
EINECS	Contact for details

Quality Control

Our N1-(3-Aminopropyl)Bleomycinamide is manufactured under strict quality systems suitable for research and pharmaceutical intermediate use. Each batch undergoes comprehensive analytical testing including HPLC for purity and identity confirmation. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing batch-specific results. Production adheres to cGMP principles where applicable to ensure consistency and reliability for critical development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.