Description

11β,17,21-Trihydroxy-16α-Methyl-Pregn-4-Ene-3,20-Dione 21-Acetate is a synthetic corticosteroid derivative, specifically the 21-acetate ester of methylprednisolone. This compound is a critical pharmaceutical intermediate with significant value in the synthesis of potent anti-inflammatory and immunosuppressive medications. It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in the development and production of steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs) like methylprednisolone and its related derivatives.
• Anti-inflammatory Drug Synthesis: Used in the production of corticosteroid medications for treating conditions such as rheumatoid arthritis, asthma, and severe allergic reactions.
• Immunosuppressive Therapy: A precursor in manufacturing drugs used to prevent organ transplant rejection and manage autoimmune diseases.
• Research & Development: Serves as a reference standard and building block in medicinal chemistry research for novel steroid-based therapies.
• Veterinary Pharmaceuticals: Employed in the formulation of anti-inflammatory and immunosuppressive treatments for animals.
• Dermatological Preparations: A component in the synthesis of topical corticosteroids for treating skin inflammations and conditions like eczema and psoriasis.

Basic Information

Product Name	11β,17,21-Trihydroxy-16α-Methyl-Pregn-4-Ene-3,20-Dione 21-Acetate
CAS No.	41020-56-8
Molecular Formula	C₂₄H₃₄O₆
Molecular Weight	418.53 g/mol
Synonyms	Methylprednisolone 21-Acetate; 16α-Methylprednisolone 21-Acetate; 11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-acetate; 16α-Methyl-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate; U-67590A; NSC-19993; Medrate Acetate
EINECS	Contact for details

Quality Control

Our 11β,17,21-Trihydroxy-16α-Methyl-Pregn-4-Ene-3,20-Dione 21-Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the high standards required for pharmaceutical synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Rotation	Contact for details
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.