Description

1-Chloro-2-(Difluoromethoxy)-4-Nitrobenzene is a specialized halogenated aromatic compound that serves as a crucial building block in advanced chemical synthesis. Its unique molecular structure, featuring both chloro and difluoromethoxy substituents on a nitrobenzene core, makes it a valuable intermediate for creating complex molecules with targeted properties. This product is primarily sought by R&D and production teams in the agrochemical and pharmaceutical industries for the development of novel active ingredients.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of modern herbicides and pesticides, where the difluoromethoxy group can enhance biological activity and environmental stability.
• Pharmaceutical Synthesis: Used as a versatile building block for constructing complex drug candidates, particularly in medicinal chemistry programs targeting new therapeutic agents.
• Material Science Research: Employed in the development of specialty polymers and liquid crystals, where its aromatic and halogenated structure can influence material properties.
• Dye and Pigment Intermediate: Acts as a starting material for synthesizing specialized dyes and organic pigments, leveraging the reactivity of the nitro and chloro groups.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create biaryl structures important in various fine chemicals.

Basic Information

Product Name	1-Chloro-2-(Difluoromethoxy)-4-Nitrobenzene
CAS No.	40319-62-8
Molecular Formula	C7H4ClF2NO3
Molecular Weight	223.56 g/mol
Synonyms	2-Chloro-1-(difluoromethoxy)-4-nitrobenzene; 4-Nitro-2-chloro-1-(difluoromethoxy)benzene; 1-Chloro-2-difluoromethoxy-4-nitrobenzene; Benzene, 1-chloro-2-(difluoromethoxy)-4-nitro-; 40319-62-8; 2-(Difluoromethoxy)-1-chloro-4-nitrobenzene
EINECS	Contact for details

Quality Control

Our production of 1-Chloro-2-(Difluoromethoxy)-4-Nitrobenzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR spectroscopy. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with every shipment. We support customer audits and can tailor specifications to meet specific project requirements for pharmaceutical or agrochemical registration.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.