Description

9-Chloro-6Alpha-Fluoro-11Beta,21-Dihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Hexanoate is a high-purity synthetic steroid derivative, specifically a halogenated and esterified pregnadiene, valued for its role as a critical pharmaceutical intermediate. Its precise molecular structure makes it an essential building block in the synthesis of advanced corticosteroid APIs, where modifications influence potency, bioavailability, and metabolic stability. This compound is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of potent anti-inflammatory and immunosuppressive medications.

Application

• Pharmaceutical Intermediate: Key precursor in the multi-step synthesis of potent topical and systemic corticosteroids.
• Active Pharmaceutical Ingredient (API) Development: Used in research for developing new steroid-based drugs with modified pharmacokinetic profiles.
• Biochemical Research: Serves as a reference standard and tool compound for studying glucocorticoid receptor interactions and steroid metabolism.
• Process Chemistry: Employed in scaling up and optimizing manufacturing routes for steroid APIs under cGMP conditions.
• Derivatization Studies: Base molecule for creating novel steroid analogs for pharmacological screening and patent development.

Basic Information

Item	Details
Product Name	9-Chloro-6Alpha-Fluoro-11Beta,21-Dihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Hexanoate
CAS No.	4891-71-8
Molecular Formula	C28H36ClFO6
Molecular Weight	523.04 g/mol
Synonyms	Clobetasol 17-Hexanoate; Clobetasol Propionate Impurity F (Hexanoate Ester); 9-Chloro-6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-hexanoate; 21-Hexanoyloxy-9-chloro-6α-fluoro-11β-hydroxy-16α-methylpregna-1,4-diene-3,20-dione; Clobetasol 21-Hexanoate; 17-Hexanoyl Clobetasol; Clobetasol Hexanoate Ester; Clobetasol Propionate Related Compound F
EINECS	Contact for details

Quality Control

Our 9-Chloro-6Alpha-Fluoro-11Beta,21-Dihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Hexanoate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.