Description

Clocortolone is a synthetic corticosteroid with potent anti-inflammatory and antipruritic properties. This compound is a critical active pharmaceutical ingredient (API) for the development of topical dermatological treatments, offering targeted therapeutic action. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on creating advanced formulations for skin conditions. The product is supplied as a high-purity material, ensuring reliability for sensitive pharmaceutical applications.

Application

• Primary Active Pharmaceutical Ingredient (API) in topical creams, ointments, and lotions for treating inflammatory skin disorders such as eczema, psoriasis, and dermatitis.
• Key intermediate in the research and development of novel corticosteroid-based therapeutics with enhanced efficacy and safety profiles.
• Reference standard in analytical laboratories for quality control and method validation in pharmaceutical manufacturing.
• Component in compounding pharmacies for preparing customized dermatological preparations.
• Subject in pharmacological studies investigating the mechanisms of topical steroid action and skin permeation.

Basic Information

Product Name	Clocortolone
CAS No.	4828-27-7
Molecular Formula	C22H27ClO4
Molecular Weight	390.90 g/mol
Synonyms	Clocortolone Pivalate (prodrug form); 9-Chloro-6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 9α-Chloro-6α-fluoro-16α-methylprednisolone; Clocortolone base; Cloderm (brand name); 1,4-Pregnadiene-3,20-dione, 9-chloro-6-fluoro-11,21-dihydroxy-16-methyl-, (6α,11β,16α)-; SQ-18566
EINECS	225-408-6

Quality Control

Our Clocortolone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. We provide full traceability and support regulatory documentation. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles is available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.