Description

Anthramycin is a potent pyrrolobenzodiazepine (PBD) antitumor antibiotic, recognized for its unique mechanism of action involving DNA alkylation. This compound is of significant interest in pharmaceutical research and development due to its high biological activity and potential as a warhead in antibody-drug conjugates (ADCs). It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology drug discovery, preclinical studies, and the development of novel targeted cancer therapies.

Application

• Oncology Research: Serves as a critical reference standard and active pharmaceutical ingredient (API) in the study of DNA-interactive antitumor agents.
• Antibody-Drug Conjugate (ADC) Development: Valued for its potent cytotoxicity, it is investigated as a payload for constructing next-generation ADCs targeting specific cancer cells.
• Mechanistic Studies: Used in biochemical and pharmacological research to understand the binding and sequence selectivity of pyrrolobenzodiazepines with DNA.
• Preclinical Pharmaceutical Development: Employed in formulation studies, stability testing, and efficacy models for novel chemotherapeutic agents.
• Chemical Biology Tool: Acts as a molecular probe to investigate cellular processes related to DNA damage and repair pathways.

Basic Information

Product Name	Anthramycin
CAS No.	4803-27-4
Molecular Formula	C₁₇H₁₉N₃O₄
Molecular Weight	329.35 g/mol
Synonyms	Anthramycin; NSC-3070; Antibiotic NSC 3070; (11aS)-8-Hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one; 1,2,3,11a-Tetrahydro-8-hydroxy-7-methoxy-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one; PBD Anthramycin
EINECS	Contact for details

Quality Control

Our Anthramycin is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. For specific purity requirements (e.g., >98%, >99%), please contact our technical team.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider keeping the product at 2-8°C. The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	Yellow to brownish powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95%
Loss on Drying	≤ 2.0 %
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.