Description

Meclorisone CAS NO 4732-48-3 is a synthetic corticosteroid compound known for its potent anti-inflammatory and immunosuppressive properties. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and safety of advanced topical and systemic pharmaceutical formulations. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development of treatments for dermatological conditions, allergic reactions, and autoimmune disorders.

Application

• Pharmaceutical API: Core active ingredient in topical creams, ointments, and lotions for treating eczema, psoriasis, and contact dermatitis.
• Veterinary Medicine: Used in formulations for managing inflammatory skin conditions and allergic reactions in animals.
• Clinical Research: Serves as a reference standard and key intermediate in pharmacological studies and new drug development.
• Compounding Pharmacy: Utilized for preparing customized medication formulations to meet specific patient needs.
• Advanced Dermatologicals: Incorporated into controlled-release and targeted delivery systems for enhanced therapeutic outcomes.

Basic Information

Product Name	Meclorisone
CAS No.	4732-48-3
Molecular Formula	C22H29FO5
Molecular Weight	392.46 g/mol
Synonyms	9α-Fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 9α-Fluoro-16α-methylprednisolone; 6α-Methyl-9α-fluoroprednisolone; 9α-Fluoro-16α-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione; NSC-47439; Meclorisone; 16α-Methyl-9α-fluoroprednisolone
EINECS	225-229-7

Quality Control

Our Meclorisone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by IR and NMR spectroscopy, to ensure compliance with ICH Q7 guidelines and customer-specific requirements. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformance to specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.