Description

Icomethasone is a synthetic corticosteroid compound with significant pharmacological activity. This high-purity intermediate is critical for the research and development of advanced anti-inflammatory and immunosuppressive pharmaceutical agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting dermatological, respiratory, and ophthalmic therapeutic areas.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potent topical and systemic corticosteroid APIs.
• Research & Development: Used in preclinical studies to investigate mechanisms of glucocorticoid receptor activity and novel drug delivery systems.
• Reference Standard: Serves as an analytical standard for quality control and method validation in pharmaceutical manufacturing.
• Dermatological Formulations: A precursor for active ingredients in creams and ointments for treating eczema, psoriasis, and dermatitis.
• Veterinary Medicine: Employed in the development of anti-inflammatory treatments for animals.

Basic Information

Product Name	Icomethasone
CAS No.	4647-20-5
Molecular Formula	C24H31FO5
Molecular Weight	418.50 g/mol
Synonyms	9α-Fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 9α-Fluoro-16α-methylprednisolone; Flumethasone; Flumetasone; 6α,9α-Difluoro-16α-methylprednisolone (common mis-association); SQ-15101; NSC-107680; Flumethasone Pivalate (ester derivative)
EINECS	225-073-9

Quality Control

Our Icomethasone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and stringent control of related substances and residual solvents. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.