Description

Dexsotalol Hydrochloride is a high-purity pharmaceutical intermediate and reference standard, essential for research and development in cardiovascular pharmacology. Its primary value lies in its role as a β-adrenergic blocking agent, specifically a class III antiarrhythmic, used in the study of cardiac electrophysiology and drug mechanisms. This compound is critical for pharmaceutical manufacturers, analytical laboratories, and academic research institutions focused on developing and testing new therapeutic agents for arrhythmia and related cardiovascular conditions.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced β-blocker and antiarrhythmic drug candidates.
• Reference Standard: Used in analytical chemistry for method development, validation, and quality control (QC/QA) testing of pharmaceutical products.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate β-adrenergic receptor blockade and cardiac potassium channel effects.
• Pharmacology Studies: Serves as a tool compound for preclinical research into the treatment of ventricular and supraventricular arrhythmias.
• Impurity Standard: Used to identify and quantify related substances in compliance with ICH guidelines for drug substance specifications.
• Academic Research: A reagent for university and institutional research programs exploring cardiovascular disease mechanisms and novel therapeutics.

Basic Information

Product Name	Dexsotalol Hydrochloride
CAS No.	4549-94-4
Molecular Formula	C18H32N2O4S • HCl
Molecular Weight	408.98 g/mol
Synonyms	d-Sotalol Hydrochloride; (S)-Sotalol Hydrochloride; Dexsotalol HCl; (S)-4'-(1-Hydroxy-2-(isopropylamino)ethyl)methanesulfonanilide Hydrochloride; MJ 1999; NSC 113939; Sotalol, d-; Sotalol Hydrochloride, (S)-; Sotalol, (S)-, Hydrochloride
EINECS	Contact for details

Quality Control

Our Dexsotalol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identification by IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) detailing all test results, ensuring compliance with research and pharmaceutical intermediate standards. Specifications can be aligned with client requirements for specific applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Chiral Purity (HPLC)	≥99.0% (d-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.