Description

6α-Fluoro-16α,17,21-Trihydroxypregna-1,4,9(11)-Triene-3,20-Dione 21-Acetate is a high-purity synthetic steroid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical pharmaceutical intermediate for the synthesis of potent glucocorticoid and anti-inflammatory agents. It is primarily utilized by pharmaceutical manufacturers and contract research organizations (CROs) engaged in the development of novel steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of advanced corticosteroid drugs, such as Triamcinolone and its analogues.
• Active Pharmaceutical Ingredient (API) Development: Used in research for developing new glucocorticoid receptor agonists with targeted therapeutic profiles.
• Anti-inflammatory Drug Research: Serves as a precursor for compounds being investigated for their potent anti-inflammatory and immunosuppressive properties.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Process Chemistry & Scale-up: Utilized in process optimization and pilot-scale manufacturing for steroid-based APIs.
• Academic & Institutional Research: Used in university and institutional labs for studying steroid biochemistry, receptor interactions, and metabolic pathways.

Basic Information

Product Name	6α-Fluoro-16α,17,21-Trihydroxypregna-1,4,9(11)-Triene-3,20-Dione 21-Acetate
CAS No.	4405-94-1
Molecular Formula	C23H27FO7
Molecular Weight	434.46 g/mol
Synonyms	9α-Fluoro-11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione 21-Acetate; 6α-Fluoro-16α,17,21-Trihydroxy-1,4,9(11)-pregnatriene-3,20-dione 21-Acetate; 6α-Fluoro-16α,17,21-Trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-Acetate; Triamcinolone 21-Acetate Intermediate; 6α-Fluoro-16α-hydroxyprednisolone 21-acetate; 6α-Fluoro-16α-hydroxy-1,4,9(11)-pregnatriene-3,20-dione-16α,17,21-triol 21-acetate
EINECS	Contact for details

Quality Control

Our 6α-Fluoro-16α,17,21-Trihydroxypregna-1,4,9(11)-Triene-3,20-Dione 21-Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards suitable for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.