Description

Pregna-1,4-Diene-3,11,20-Trione is a high-purity steroid derivative and a key synthetic intermediate in the pharmaceutical industry. Its value lies in its role as a crucial building block for the synthesis of more complex corticosteroid and progestogen APIs. This compound is essential for manufacturers in the pharmaceutical and fine chemical sectors requiring reliable, high-quality raw materials for research, development, and production.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly corticosteroids and other steroidal drugs.
• Research & Development: Used in laboratory settings for the discovery and development of new therapeutic agents targeting hormonal pathways and inflammatory conditions.
• Fine Chemical Synthesis: Serves as a specialized building block for creating complex organic molecules in custom synthesis and process chemistry.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development, validation, and impurity profiling of related steroid compounds.

Basic Information

Product Name	Pregna-1,4-Diene-3,11,20-Trione
CAS No.	4368-11-0
Molecular Formula	C21H26O3
Molecular Weight	326.43 g/mol
Synonyms	1,4-Pregnadiene-3,11,20-trione; 11-Ketoprednisone; 11-Oxoprednisone; 17α,21-Dihydroxypregna-1,4-diene-3,11,20-trione; NSC 10483; δ1-Cortisone; 11-Oxo-17α,21-dihydroxypregna-1,4-diene-3,20-dione
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Diene-3,11,20-Trione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications for pharmaceutical intermediates. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.