Description

9-Fluoro-11Beta,17-Dihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 17-Propionate is a high-purity synthetic corticosteroid derivative, specifically a fluorinated and esterified pregnadiene. This compound is valued for its potent anti-inflammatory and immunosuppressive pharmacological activity, making it a critical advanced pharmaceutical intermediate in the synthesis of modern steroid-based therapeutics. It is primarily required by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers for the development and production of specialized corticosteroid medications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potent topical and systemic corticosteroids, such as fluticasone propionate and related analogs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new anti-inflammatory drugs.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a precursor in the multi-step synthesis of final, formulated corticosteroid APIs under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation of steroid assays.
• Dermatological Formulations: A critical component in the development of creams, ointments, and lotions for treating eczema, psoriasis, and other inflammatory skin conditions.
• Respiratory Therapeutics: Used in the production of inhaled corticosteroids for managing asthma and chronic obstructive pulmonary disease (COPD).

Basic Information

Product Name	9-Fluoro-11Beta,17-Dihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 17-Propionate
CAS No.	4351-48-8
Molecular Formula	C25H33FO5
Molecular Weight	432.53 g/mol
Synonyms	Fluticasone Propionate EP Impurity C; 6α,9α-Difluoro-11β,17α-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17-propionate (related isomer); 9α-Fluoro-11β,17α-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17α-propionate; S-Fluoromethyl 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate 17-propionate intermediate; Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17-dihydroxy-16β-methyl-, 17-propionate; 4351-48-8; Fluticasone related compound C
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,17-Dihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 17-Propionate is manufactured and controlled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC purity assay, related substance profiling, and identity confirmation (IR, MS) to ensure it meets exacting standards for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with full traceability are provided for every shipment. We can supply material compliant with various pharmacopeial monographs, including EP and USP, upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under conditions of low humidity to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.