Description

9-Chloro-6α-Fluoro-11β-Hydroxy-21-Acetoxy-16α-Methylpregna-1,4-Diene-3,20-Dione is a high-purity synthetic steroid intermediate of significant importance in advanced pharmaceutical manufacturing. This compound serves as a critical precursor in the synthesis of potent topical corticosteroids, enabling the development of specialized anti-inflammatory and immunosuppressive medications. It is essential for R&D laboratories and production facilities focused on dermatological and ophthalmic drug development, where precise chemical structure and high purity are paramount for efficacy and regulatory compliance.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced corticosteroid APIs like Halobetasol Propionate and related analogues.
• Dermatological Drug Development: Used in R&D for creating high-potency topical treatments for psoriasis, eczema, and other inflammatory skin conditions.
• Ophthalmic Formulation Research: Employed in the development of steroid treatments for eye inflammation and post-surgical care.
• Process Chemistry & Scale-Up: Serves as a standard reference material and starting material for process optimization and GMP manufacturing.
• Academic & Institutional Research: Utilized in pharmacological studies investigating steroid receptor activity and structure-activity relationships (SAR).
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for client-specific API synthesis projects.

Basic Information

Product Name	9-Chloro-6α-Fluoro-11β-Hydroxy-21-Acetoxy-16α-Methylpregna-1,4-Diene-3,20-Dione
CAS No.	4258-85-9
Molecular Formula	C₂₄H₃₀ClFO₅
Molecular Weight	452.95 g/mol
Synonyms	Halobetasol Propionate Intermediate; 9-Chloro-6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate; 21-Acetoxy-9-chloro-6α-fluoro-11β-hydroxy-16α-methylpregna-1,4-diene-3,20-dione; 9-Chloro-6α-fluoro-11β-hydroxy-16α-methyl-17,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate; Ultravate Intermediate; (6α,11β,16α)-9-Chloro-6-fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-acetate
EINECS	Contact for details

Quality Control

Our 9-Chloro-6α-Fluoro-11β-Hydroxy-21-Acetoxy-16α-Methylpregna-1,4-Diene-3,20-Dione is manufactured under strict quality systems suitable for pharmaceutical intermediate use. Each batch undergoes rigorous analytical testing including HPLC for purity, identity confirmation by IR and NMR, and control of specified impurities. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all test results against agreed specifications. Our quality commitment ensures traceability, consistency, and supports our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed after opening to minimize exposure to atmospheric moisture and light. For long-term storage, consider using desiccants and maintaining an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.