Description

(S)-(-)-Propranolol Hydrochloride CAS NO 4199-10-4 is the single enantiomer, S(-)-form, of the widely used non-selective β-adrenergic receptor antagonist. This high-purity chiral building block is critical for pharmaceutical research and development, particularly in studying stereospecific drug activity and metabolism. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in cardiovascular research, chiral pharmacology, and the development of enantiomerically pure active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Reference Standard: Used as a certified standard for quality control and analytical method development in API and finished drug product manufacturing.
• Chiral Pharmacology Research: Essential for investigating the stereospecific binding, efficacy, and pharmacokinetic profile of β-blockers, enabling more targeted drug design.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a key chiral intermediate in the synthesis of enantiomerically pure propranolol and related β-adrenergic blocking agents.
• Metabolic and Toxicology Studies: Employed in preclinical and clinical studies to understand the distinct metabolic pathways and safety profiles of individual enantiomers.
• Biochemical Assay Development: Used in vitro to study receptor-ligand interactions and for calibrating assays targeting β-adrenergic receptors.
• Academic & Institutional Research: A fundamental tool for universities and research institutes focusing on cardiovascular physiology, autonomic nervous system regulation, and chiral separation sciences.

Basic Information

Product Name	(S)-(-)-Propranolol Hydrochloride
CAS No.	4199-10-4
Molecular Formula	C16H22ClNO2 • HCl
Molecular Weight	295.81 g/mol (Free base: 259.34)
Synonyms	(S)-(-)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol Hydrochloride; (S)-Propranolol HCl; L-Propranolol Hydrochloride; (-)-Propranolol Hydrochloride; S(-)-Propranolol Hydrochloride; 4199-10-4; (2S)-1-(1-Methylethyl)amino-3-(1-naphthalenyloxy)-2-propanol Hydrochloride
EINECS	224-076-7

Quality Control

Our (S)-(-)-Propranolol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet stringent specifications. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing results for assay, chiral purity, related substances, and residual solvents. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical intermediates and reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.