Description

2-Fluoro-5-(Trifluoromethyl)Benzonitrile is a high-value fluorinated aromatic nitrile building block, distinguished by its unique combination of fluorine atoms and a nitrile functional group. This structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where electronic properties and metabolic stability are paramount. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel compounds with enhanced performance characteristics.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing trifluoromethyl and fluorine motifs to improve lipophilicity and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to increased biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), influencing charge transport and emission properties.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed reactions (e.g., Suzuki, Sonogashira) as an electrophilic partner due to the reactivity of the nitrile and halogen substituents.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing complex fluorinated aromatic systems for various high-value applications.

Basic Information

Product Name	2-Fluoro-5-(Trifluoromethyl)Benzonitrile
CAS No.	4088-84-0
Molecular Formula	C8H3F4N
Molecular Weight	189.11 g/mol
Synonyms	2-Fluoro-α,α,α-trifluoro-p-tolunitrile; 5-Cyano-2-fluorobenzotrifluoride; 2-Fluoro-5-(trifluoromethyl)benzonitrile; 2-Fluoro-α,α,α-trifluoro-p-tolunitrile; 2-Fluoro-5-(trifluoromethyl)phenyl cyanide; 2-Fluoro-α,α,α-trifluoro-4-cyanotoluene; 4-Cyano-2-fluorobenzotrifluoride; Benzonitrile, 2-fluoro-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.