Description

5α-Dihydrocortisol 21-Acetate is a synthetic steroid derivative, specifically an acetate ester of 5α-dihydrocortisol, which serves as a crucial intermediate in advanced pharmaceutical synthesis. This compound is valued for its role in the research and development of novel corticosteroid analogs and other bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic research institutions focused on endocrinology and synthetic organic chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of specialized corticosteroid drugs and their metabolites.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development, validation, and quality control testing of steroid-based products.
• Biochemical Research: Employed in metabolic pathway studies to investigate the activity and transformation of cortisol and related steroids.
• Process Development: Serves as a critical starting material or intermediate for scaling up production processes in GMP environments.

Basic Information

Product Name	5α-Dihydrocortisol 21-Acetate
CAS No.	4004-68-6
Molecular Formula	C23H34O6
Molecular Weight	406.52 g/mol
Synonyms	11β,17α,21-Trihydroxy-5α-pregnane-3,20-dione 21-acetate; 5α-Dihydrohydrocortisone 21-acetate; 21-Acetoxy-5α-dihydrocortisol; (5α)-11β,17,21-Trihydroxypregnane-3,20-dione 21-acetate; 5α-Pregnan-11β,17α,21-triol-3,20-dione 21-acetate; Cortisol 21-acetate, 5α-dihydro-; 5α-Dihydrocortisol acetate
EINECS	Contact for details

Quality Control

Our 5α-Dihydrocortisol 21-Acetate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical intermediates and research chemicals. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.