Description

3-Fluoro-5-Nitrotoluene is a versatile fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its unique structure, featuring both a nitro and a fluorine substituent on the toluene backbone, makes it a critical building block for creating complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for compounds requiring a fluorinated aromatic moiety.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, pesticides, and fungicides, where the fluorine atom can enhance biological activity and stability.
• Dye and Pigment Manufacturing: Serves as a starting material for synthesizing specialized dyes and organic pigments.
• Liquid Crystal & Electronic Materials: A valuable building block in the development of fluorinated liquid crystals and organic electronic materials.
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing biaryl systems.
• Organic Synthesis Research: Used in academic and industrial R&D for exploring new fluorination pathways and nitro-group transformations.

Basic Information

Product Name	3-Fluoro-5-Nitrotoluene
CAS No.	499-08-1
Molecular Formula	C7H6FNO2
Molecular Weight	155.13 g/mol
Synonyms	1-Fluoro-3-methyl-5-nitrobenzene; 3-Methyl-5-nitrofluorobenzene; 5-Nitro-3-fluorotoluene; 3-Fluoro-5-methylnitrobenzene; m-Fluoro-m-nitrotoluene; Toluene, 3-fluoro-5-nitro-; Benzene, 1-fluoro-3-methyl-5-nitro-
EINECS	207-879-6

Quality Control

Our 3-Fluoro-5-Nitrotoluene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.