Description

Doxylamine is a first-generation ethanolamine antihistamine with pronounced sedative properties. Its primary commercial value lies in its efficacy as a sleep aid and in multi-symptom relief formulations, making it a critical active pharmaceutical ingredient (API). This compound is essential for manufacturers in the pharmaceutical and over-the-counter (OTC) drug industries. Doxylamine CAS NO 469-21-6 is known for its reliable performance in formulations requiring a sedating antihistamine effect.

Application

• Sleep Aid Formulations: Primary active ingredient in OTC sleep-inducing tablets and liquid medications.
• Cold & Allergy Medications: Key component in multi-symptom night-time relief formulas for its antihistamine and sedative effects.
• Antiemetic Preparations: Used in formulations to prevent nausea and vomiting, often in combination with other APIs.
• Veterinary Pharmaceuticals: Employed in sedative and antiemetic applications for animal health.
• Research & Development: Serves as a reference standard and building block in pharmacological and synthetic chemistry research.
• Contract Manufacturing: Supplied to pharmaceutical companies for the production of generic and branded drug products.

Basic Information

Product Name	Doxylamine
CAS No.	469-21-6
Molecular Formula	C17H22N2O
Molecular Weight	270.37 g/mol
Synonyms	Doxylamine Succinate (common salt form); 2-[α-[2-(Dimethylamino)ethoxy]-α-methylbenzyl]pyridine; N,N-Dimethyl-2-(1-phenyl-1-(2-pyridyl)ethoxy)ethylamine; Histadoxylamine; Decapryn; Unisom (brand name sleep aid); Meractin (brand name); C17-Antihistamine
EINECS	207-420-7

Quality Control

Our Doxylamine is manufactured and tested under a strict quality management system. We provide material that meets pharmaceutical-grade standards, with specifications aligned with major pharmacopoeial requirements. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing purity, identity, and impurity profiles to ensure compliance with your formulation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.