Description

Dexamethasone 21-(Sodium Sulphate) is a water-soluble prodrug ester of the potent glucocorticoid dexamethasone. This chemical modification enhances its solubility for formulation in aqueous systems, making it a critical intermediate in the development of injectable and ophthalmic pharmaceutical products. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of anti-inflammatory and immunosuppressive medications.

Application

• Pharmaceutical Intermediate: Key starting material for the synthesis of injectable dexamethasone formulations.
• Ophthalmic Solutions: Used in the manufacture of eye drops and other topical solutions for treating ocular inflammation.
• Veterinary Medicine: Employed in the production of anti-inflammatory treatments for animals.
• Research & Development: Serves as a standard or reagent in biochemical and pharmacological research on steroid action and metabolism.
• Advanced Drug Delivery Systems: Investigated for use in controlled-release and targeted drug delivery platforms.

Basic Information

Product Name	Dexamethasone 21-(Sodium Sulphate)
CAS No.	466-11-5
Molecular Formula	C22H29FO8S • Na
Molecular Weight	516.52 g/mol
Synonyms	Dexamethasone Sodium Sulfate; Dexamethasone 21-Sodium Sulfate; Dexamethasone 21-Sulfate Sodium Salt; 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(sodium sulfate); Sodium Dexamethasone Sulfate; Dexamethasone 21-Hemisulfate Sodium Salt
EINECS	Contact for details

Quality Control

Our Dexamethasone 21-(Sodium Sulphate) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting high standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing specific results for assay, related substances, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.