Description

4-Fluorophenylacetonitrile is a versatile and high-value fluorinated aromatic nitrile building block. This compound is essential for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, due to the unique properties imparted by the fluorine atom. It is primarily sought after by research institutions and industrial manufacturers engaged in the development of active pharmaceutical ingredients (APIs), advanced agrochemicals, and specialty materials. Our supply of 4-Fluorophenylacetonitrile CAS NO 459-22-3 is characterized by consistent high purity and reliable availability to support critical R&D and production processes.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, including potential CNS agents, anti-inflammatory drugs, and kinase inhibitors.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides where the fluorine moiety enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies.
• Organic Synthesis Building Block: Employed in various name reactions (e.g., nucleophilic substitution, cyano-group transformations) to introduce the 4-fluorobenzyl moiety.
• Chemical Research & Development: Utilized in academic and industrial labs for exploring new fluorination chemistry and developing novel synthetic methodologies.
• Specialty Polymer Modifier: Can be incorporated into polymer backbones to alter material properties such as thermal stability and solubility.

Basic Information

Product Name	4-Fluorophenylacetonitrile
CAS No.	459-22-3
Molecular Formula	C8H6FN
Molecular Weight	135.14 g/mol
Synonyms	(4-Fluorophenyl)acetonitrile; 4-Fluorobenzyl cyanide; p-Fluorophenylacetonitrile; 2-(4-Fluorophenyl)acetonitrile; (p-Fluorophenyl)acetonitrile; 4-Fluorobenzeneacetonitrile; α-Cyano-4-fluorotoluene; UNII-9K3C8S5A4F
EINECS	207-300-6

Quality Control

Our 4-Fluorophenylacetonitrile is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality parameters. Our quality systems are designed to meet the rigorous standards required for pharmaceutical and advanced chemical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizers, strong bases, and sources of ignition. The container should be kept tightly sealed to minimize moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Density (20°C)	~1.14 g/cm³
Refractive Index (n20D)	~1.495

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.